Prostaglandins Leukot.Essent.Fatty Acids 1993;48(5):363-372. A preliminary report. Itching. Oncol Res 2014;21(5):247-59. ... uses, and risks of cloves. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. View abstract. Investigation on the phenolics of some spices having pharmacotherapeuthic properties. Eugenol is very fragrant and gives allspice and clove their distinctive smell. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. J Endod. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. The oil has been used as an expectorant and antiemetic with inconsistent clinical results. 1998;26(2):118-122. If you have natural clove leaves, you can simply place the leaf on the painful tooth and leave it there for a few minutes, or, if you have it in liquid form, simply place a drop on the area. Rodrigues, T. G., Fernandes, A., Jr., Sousa, J. P., Bastos, J. K., and Sforcin, J. M. In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages. View abstract. J Dent.Res. McDougal, R. A., Delano, E. O., Caplan, D., Sigurdsson, A., and Trope, M. Success of an alternative for interim management of irreversible pulpitis. Rahim, Z. H. and Khan, H. B. View abstract. Cloves are the flower buds of the clove tree, an evergreen also known as Syzygium aromaticum ().. Found in both whole and ground forms, this … 1989;30(3):129-135. Xing, F., Tan, Y., Yan, G. J., Zhang, J. J., Shi, Z. H., Tan, S. Z., Feng, N. P., and Liu, C. H. Effects of Chinese herbal cataplasm Xiaozhang Tie on cirrhotic ascites. View abstract. Do not use if you're on blood-thinning medications. 2018;67(2):e38-e39. Clove leaf oil is extracted from leaves of clove tree. It can prove effective in curing acne, reduce swelling and kill infectious bacteria at the same time. Prostaglandins Leukot.Essent.Fatty Acids 2006;74(1):23-27. 1st ed. 1999;36(5):625-629. 1987;66(3):774-777. Kirsch CM, Yenokida GG, Jensen WA, et al. Lee, Y. Y., Hung, S. L., Pai, S. F., Lee, Y. H., and Yang, S. F. Eugenol suppressed the expression of lipopolysaccharide-induced proinflammatory mediators in human macrophages. When derived entirely from the leaf, it’s 77% eugenol. Bull.Tokyo Dent Coll. WebMD does not provide medical advice, diagnosis or treatment. View abstract. Nelson, R. L., Thomas, K., Morgan, J., and Jones, A. View abstract. View abstract. 2009;69(5):527-528. 2006;85(10):900-904. Hackett, P. H., Rodriguez, G., and Roach, R. C. Clove cigarettes and high-altitude pulmonary edema. Clove buds yield approximately 15% to 20% of a volatile oil that is responsible for the characteristic aroma and flavor. Clove has a long history of culinary and medicinal use. Swelling (inflammation) and sores inside the mouth (oral mucositis). View abstract. 1986;65(1):53-56. Gen Pharmacol 1996;27:629-33. View abstract. Kaya GS, Yapici G, Savas Z, et al. An extract of Syzygium aromaticum represses genes encoding hepatic gluconeogenic enzymes. Contraindications have not been identified. Clove leaf oil is used in many products like toothpastes, soaps, toiletries, cosmetics, perfumes and candles. Clinical evaluation of three restorative materials applied in a minimal intervention caries treatment approach. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Clove essential oil was also found to exhibit anticariogenic and cytotoxic activity against a large number of oral pathogens ().Eugenol and eugenyl acetate are the two active components in clove essential oil that help prevent decalcification or dental erosion ().Clove oil is most effective against microorganisms that cause dental caries ().2. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. View abstract. Medically reviewed by Drugs.com. Ibrahim IM, Abdel Kareem IM, Alghobashy MA. Blood Coagul.Fibrinolysis 1992;3(5):665-668. Clove oil contains a compound called eugenol which is known for its antibacterial properties. View abstract. 2005;15(6):437-447. (check all that apply), What factors are most important to you? Annales: Economies, Societes, Civilisations 1980;35(3-4):801-815. Int J Paediatr.Dent. If it is used in an oil, lotion or cream applied to the skin, the concentration should be well below 1%. View abstract. 1998;14(2):72-74. The FDA now believes there is not enough evidence to rate eugenol as effective for toothache pain. Posted November 29, 2012 by Jeff Callahan. Kharfi, M., El, Fekih N., Zayan, F., Mrad, S., and Kamoun, M. R. [Temporary tatooing: black henna or harkous?]. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. View abstract. This is only a brief summary of general information about this product. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . View abstract. It is indigenous to the celebrated Spice Islands, the Moluccas Islands in Indonesia. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. People use the oils, dried flower buds, leaves, and stems to make medicine. A 1% clove oil cream has been used in the treatment of anal fissures.27 Clove oil gel (2:3 vol/vol with glycerin) has been used on induced buccal mucosa pain.13, Information regarding safety and efficacy in pregnancy and lactation is lacking. Singh, U. P., Singh, D. P., Maurya, S., Maheshwari, R., Singh, M., Dubey, R. S., and Singh, R. B. View abstract. Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., and Patapoutian, A. Clove extract inhibits tumor growth and promotes cell cycle arrest and apoptosis. View abstract. Hum.Exp Toxicol. Srivastava, K. C. and Malhotra, N. Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. View abstract. View abstract. J Am Dent.Assoc 2004;135(12):1707-1712. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? Islam, S. N., Ferdous, A. J., Ahsan, M., and Faroque, A. In general, the level of clove used in foods does not exceed 0.24%; the oil is not used in amounts greater than 0.06%. All rights reserved. While all types of oil share many of the same clove oil uses, their differences in Eugenol content make some better suited for certain applications than others. Apply this gel over face to cure acne. View abstract. There are many uses of olive leaf extract. Early research shows that putting a solution containing clove oil gel on the skin can help with severe itching. Allergy 2008;63(1):137-138. Yang, B. H., Piao, Z. G., Kim, Y. 2007;21(6):501-506. J Indian Soc Periodontol 2014;18(3): 316-20. This survey is being conducted by the WebMD marketing sciences department. There are limited studies to support therapeutic dosing for clove oil. Anti-Giardia activity of Syzygium aromaticum essential oil and eugenol: effects on growth, viability, adherence and ultrastructure. One of the most popular uses of clove leaf oil is that it serves as a good remedy for toothaches and other oral-related problems, thanks to its antibacterial and anodyne properties. Dorman HJ, Deans SG. Historical uses and importance of Clove leaf oil: Clove is an evergreen tree, which is found growing in plenty in Sri Lanka, Madagascar, Zanzibar, Singapore, Mauritius, Pakistan, Tanzania, and India (Kerala and Tamilnadu). Sosto, F. and Benvenuti, C. Controlled study on thymol + eugenol vaginal douche versus econazole in vaginal candidiasis and metronidazole in bacterial vaginosis. Where did you or where do you plan to purchase this product? Bhalla, M. and Thami, G. P. Acute urticaria due to dental eugenol. Southeast Asian J Trop.Med Public Health 2004;35(2):325-333. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. 2008;46(10):3333-3338. This oil can cause skin irritation. Choi HK, Jung GW, Moon KH, et al. The stems yield approximately 5% of the oil, and the leaves yield approximately 2%. A 50% ethanolic extract of clove enhanced the sexual activity of male rats without any adverse or overt toxicological events.30, 31, Clove oil possesses mosquito repellant and other insecticidal activity.3, 32 Eugenol possesses marked antipyretic activity in animals, similar to that of acetaminophen. Occupational asthma and rhinitis caused by eugenol in a hairdresser. Ann Agric.Environ.Med. View abstract. Jadhav, B. K., Khandelwal, K. R., Ketkar, A. R., and Pisal, S. S. Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases. Cortés-Rojas DF, de Souza CR, Oliveira WP. Mishra, R. K. and Singh, S. K. Safety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in mice. Clove and clove oils are used safely in foods, beverages, and toothpastes. Clove contains eugenol. Clove oil and eugenol, one of the chemicals it contains, have long been applied to the teeth and gums for toothache, but the U.S. Food and Drug Administration (FDA) has reclassified eugenol, downgrading its effectiveness rating. View abstract. View abstract. Yarnell E and Abascal K. Botanical medicines for headache. Evaluation of the health hazard of clove cigarettes. Information from this source is evidence-based and objective, and without commercial influence. Trongtokit, Y., Rongsriyam, Y., Komalamisra, N., Krisadaphong, P., and Apiwathnasorn, C. Laboratory and field trial of developing medicinal local Thai plant products against four species of mosquito vectors. Saeed, S. A. and Gilani, A. H. Antithrombotic activity of clove oil. Its gland-dotted leaves are small, simple, and opposite. Robbers JE, Tyler VE. Friedman, M., Henika, P. R., Levin, C. E., and Mandrell, R. E. Antibacterial activities of plant essential oils and their components against Escherichia coli O157:H7 and Salmonella enterica in apple juice. Effect of eugenol on macrophage adhesion in vitro to plastic surfaces. View abstract. Sign Up to Receive Our Free Coroanvirus Newsletter. Fu, Y., Zu, Y., Chen, L., Shi, X., Wang, Z., Sun, S., and Efferth, T. Antimicrobial activity of clove and rosemary essential oils alone and in combination. The clove tree is an evergeen that grows to about 8 to 12 metres (25 to 40 feet) in height. 2005;30(4):533-539. Contact Dermatitis 1996;35:157-62. Quirce, S., Fernandez-Nieto, M., del, Pozo, V, Sastre, B., and Sastre, J. Chaieb, K., Hajlaoui, H., Zmantar, T., Kahla-Nakbi, A. Arzneimittelforschung. 2003;82(10):781-785. Yakushigaku.Zasshi 2001;36(2):167-170. It should be avoided during pregnancy. View abstract. View abstract. Raghavenra, H., Diwakr, B. T., Lokesh, B. R., and Naidu, K. A. Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. View abstract. Pongprayoon, U., Baeckstrom, P., Jacobsson, U., Lindstrom, M., and Bohlin, L. Compounds inhibiting prostaglandin synthesis isolated from Ipomoea pes-caprae. View abstract. 2008;87(2):137-141. & Perry (Myrtaceae) in animal models. Prabuseenivasan, S., Jayakumar, M., and Ignacimuthu, S. In vitro antibacterial activity of some plant essential oils. View abstract. 2004;4(4):27-42. 2009;35(2):229-232. Clove cigarette smoking: biochemical, physiological, and subjective effects. Local anaesthetic activity of beta-caryophyllene. Pak.J Pharm.Sci 1990;3(1):1-5. Farmaco 2001;56(5-7):387-389. Alternative & Complementary Therapies (England) 2007;13:148-152. Toothache. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Phytother Res 2005;19(4):303-309. Elwakeel, H. A., Moneim, H. A., Farid, M., and Gohar, A. View abstract. Small tears in the lining of the anus (anal fissures). To Promote Oral Health. View abstract. Not recommended for leave-on products like lotion. Clove oil possesses free radical scavenging and iron chelating properties and inhibits lipid peroxidation to a greater extent than eugenol alone.3, 8, 28, 29 Clinical applications are lacking. Just mix 2 to 3 drops of pure clove oil with your skin cream and apply gently. Clove tea was used to relieve nausea. Clove and clove oils are used safely in foods, beverages, and toothpastes. Effect of non-eugenol- and eugenol-containing periodontal dressings on the incidence and severity of pain after periodontal soft tissue surgery. They are a popular spice that people use in soups, stews, meats, sauces, and rice dishes. Int J Oral Maxillofac.Surg. View abstract. A. Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. View abstract. Zanata, R. L., Navarro, M. F., Barbosa, S. H., Lauris, J. R., and Franco, E. B. Non surgical therapy for anal fissure. View abstract. J Appl Microbiol 2000;88:308-16. 2007;21(10):989-994. Evaluation of topical liposome incorporated clove oil in the treatment of idiopathic palmar hyperhidrosis: Single-blinded placebo-controlled study. In addition, the bud contains a tannin complex, gum and resin, and a number of glucosides of sterols. Kumar, P., Ansari, S. H., and Ali, J. Herbal remedies for the treatment of periodontal disease--a patent review. 2002;65(11):1517-1521. Eur.J Pediatr 2005;164(8):520-522. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. Muniz, L. and Mathias, P. The influence of sodium hypochlorite and root canal sealers on post retention in different dentin regions. View abstract. Sanchez-Perez, J. and Garcia-Diez, A. Washington, DC: American Pharmaceutical Association, 1996. 2008;34(2):176-180. J Dent.Res. 2002;65(10):1545-1560. J Endod. J Ethnopharmacol 2002;83:153-9. This product may be unsafe when used before surgery or other medical procedures. Hartnoll, G., Moore, D., and Douek, D. Near fatal ingestion of oil of cloves. Effect of Syzygium aromaticum extract on immediate hypersensitivity in rats. View abstract. Kadey M. Lost in spice. J Drug Target 2005;13(10):555-561. View abstract. Originating in Indonesia, cloves are dried flower buds from the clove tree. Anti-Aging: Clove oil can help to lessen signs of ageing, wrinkles, and sagging skin. J Dent.Res. J Herb.Pharmacother. View abstract. Kim, S. S., Oh, O. J., Min, H. Y., Park, E. J., Kim, Y., Park, H. J., Nam, Han Y., and Lee, S. K. Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Jayashankar, S., Panagoda, G. J., Amaratunga, E. A., Perera, K., and Rajapakse, P. S. A randomised double-blind placebo-controlled study on the effects of a herbal toothpaste on gingival bleeding, oral hygiene and microbial variables. Clove bud oil produces a strong painkiller-like activity. Prasad RC, Herzog B, Boone B, et al. Uses of Olive Leaf Extract. Fabio, A., Cermelli, C., Fabio, G., Nicoletti, P., and Quaglio, P. Screening of the antibacterial effects of a variety of essential oils on microorganisms responsible for respiratory infections. Park, C. K., Li, H. Y., Yeon, K. Y., Jung, S. J., Choi, S. Y., Lee, S. J., Lee, S., Park, K., Kim, J. S., and Oh, S. B. Eugenol inhibits sodium currents in dental afferent neurons. 2004;42(1):89-92. People use the oils, dried flower buds, leaves, and stems to make medicine. Select one or more newsletters to continue. Phytother.Res. View abstract. Clove has been reported to have antiplatelet effects; however, case reports are lacking.37, 38, 39 The following are possible based on pharmacologic activity of clove or its ingredients: additive effects of analgesics; anticoagulant medications (including warfarin), aspirin or aspirin-containing products, NSAIDs, or antiplatelet agents (eg, ticlopidine, clopidogrel, dipyridamole). Scarparo, R. K., Grecca, F. S., and Fachin, E. V. Analysis of tissue reactions to methacrylate resin-based, epoxy resin-based, and zinc oxide-eugenol endodontic sealers. This information relates to an herbal, vitamin, mineral or other dietary supplement. View abstract. Clove bud essential oil blends well with other spice oils like black pepper (Piper nigrum) and ginger (Zingiber officinale), floral oils like geranium (Pelargonium graveolens), German chamomile (Matricaria recutita), and ylang ylang (Cananga odorata), as well as many others. View abstract. Clove has historically been used for its antiseptic and analgesic effects.
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